Mix Tamarind Base: In a bowl, combine the tamarind paste and water. Stir until smooth.
Add Sweetness and Spice: Mix in the brown sugar, chili powder, garlic powder, onion powder, and salt until well incorporated.
Adjust the Flavor: Squeeze in the lime juice and taste. Adjust sweetness or spiciness to your preference.
Simmer the Sauce: Pour the mixture into a saucepan and heat over medium-low, stirring occasionally. Let it simmer for about 5-10 minutes until slightly thickened.
Cool and Store: Remove from heat and let it cool. Transfer to a glass jar and refrigerate. This sauce can be stored for up to two weeks.