Sprinkle catfish fillets on both sides with salt and pepper.
If desired, douse catfish with hot sauce for extra flavor.
Let seasoned catfish stand at room temperature for 10 minutes.
In a shallow dish, combine self-rising flour and self-rising cornmeal.
Dredge each catfish fillet thoroughly in the flour-cornmeal mixture, coating both sides completely.
Heat bacon drippings or shortening in a large skillet over medium-high heat.
Carefully place coated catfish in hot oil and fry for 8-10 minutes, turning once halfway through.
Cook until golden brown on both sides and fish flakes easily with a fork.
Remove from oil and drain on paper towels before serving.